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Cellular Copper Homeostasis: Current Concepts on its interplay with glutathione homeostasis and its implication in Physiology and Human Diseases

Abstract

Copper is a trace element essential for almost all living organisms. But level of intracellular copper needs to be tightly regulated. Dysregulation of cellular copper homeostasis leading to various diseases demonstrate the importance of this tight regulation. Copper homeostasis is regulated not only within the cell but also within individual intracellular compartments. Inactivation of export machinery results in excess copper being redistributed into various intracellular organelles. Recent evidences suggest involvement of glutathione to play important role in regulating copper entry and intracellular copper homeostasis. Therefore interplay of both homeostasis might play important role within the cell. Similar to copper, glutathione balance is tightly regulated within individual cellular compartments. The review explores the existing literature on the role of glutathione in regulating cellular copper homeostasis. On one hand, interplay of glutathione and copper homeostasis performs important role in normal physiological processes, example neuronal differentiation. On the other hand, perturbation of the interplay might play key role in the pathogenesis of copper homeostasis disorders.

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Publication details

The article was received on 08 Mar 2017, accepted on 09 Jun 2017 and first published on 09 Jun 2017


Article type: Critical Review
DOI: 10.1039/C7MT00066A
Citation: Metallomics, 2017, Accepted Manuscript
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    Cellular Copper Homeostasis: Current Concepts on its interplay with glutathione homeostasis and its implication in Physiology and Human Diseases

    A. Bhattacharjee, K. Chakraborty and A. Shukla, Metallomics, 2017, Accepted Manuscript , DOI: 10.1039/C7MT00066A

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