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Issue 5, 2017
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Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

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Abstract

The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4′-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′–3′ direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.

Graphical abstract: Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex

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Publication details

The article was received on 23 Feb 2017, accepted on 11 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7MT00052A
Citation: Metallomics, 2017,9, 494-500
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    Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

    O. Hrabina, J. Kasparkova, T. Suchankova, V. Novohradsky, Z. Guo and V. Brabec, Metallomics, 2017, 9, 494
    DOI: 10.1039/C7MT00052A

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