Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

Author affiliations

Abstract

The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH3)2Cl]2(4,4′-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′–3′ direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.

Graphical abstract: Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 23 Feb 2017, accepted on 11 Apr 2017 and first published on 12 Apr 2017


Article type: Paper
DOI: 10.1039/C7MT00052A
Citation: Metallomics, 2017, Advance Article
  •   Request permissions

    Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

    O. Hrabina, J. Kasparkova, T. Suchankova, V. Novohradsky, Z. Guo and V. Brabec, Metallomics, 2017, Advance Article , DOI: 10.1039/C7MT00052A

Search articles by author