Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Iron isotopic composition of blood serum in anemia of chronic kidney disease

Author affiliations


Chronic kidney disease (CKD) is a general term for disorders that affect the structure and function of the kidneys. Iron deficiency (ID) and anemia occur in the vast majority of CKD patients, most of whom are elderly. However, establishing the cause of anemia in CKD, and therefore making an informed decision concerning the corresponding therapeutic treatment, is still a challenge. High-precision Fe isotopic analysis of blood serum samples of CKD patients with and without ID/anemia was performed via multi-collector inductively coupled plasma-mass spectrometry (MC-ICP-MS) for such a purpose. Patients with CKD and/or iron disorders showed a heavier serum Fe isotopic composition than controls. Many clinical parameters used for the diagnosis and follow-up of anemia correlated significantly with the serum Fe isotopic composition. In contrast, no relation was observed between the serum Fe isotopic composition and the estimated glomerular filtration rate as a measure of kidney function. Among the CKD patients, the serum Fe isotopic composition was substantially heavier in the occurrence of ID anemia, while erythropoietin-related anemia did not exert this effect. The Fe isotopic composition can thus be useful for distinguishing these different types of anemias in CKD patients, i.e. ID anemia vs. erythropoietin-related anemia.

Graphical abstract: Iron isotopic composition of blood serum in anemia of chronic kidney disease

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 26 Jan 2017, accepted on 10 Mar 2017 and first published on 10 Mar 2017

Article type: Paper
DOI: 10.1039/C7MT00021A
Citation: Metallomics, 2017, Advance Article
  •   Request permissions

    Iron isotopic composition of blood serum in anemia of chronic kidney disease

    Y. Anoshkina, M. Costas-Rodríguez, M. Speeckaert, W. Van Biesen, J. Delanghe and F. Vanhaecke, Metallomics, 2017, Advance Article , DOI: 10.1039/C7MT00021A

Search articles by author