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Issue 3, 2017
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Iron acquisition in fungal pathogens of humans

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Abstract

The devastating infections that fungal pathogens cause in humans are underappreciated relative to viral, bacterial and parasitic diseases. In recent years, the contributions to virulence of reductive iron uptake, siderophore-mediated uptake and heme acquisition have been identified in the best studied and most life-threatening fungal pathogens: Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In particular, exciting new work illustrates the importance of iron acquisition from heme and hemoglobin in the virulence of pathogenic yeasts. However, the challenge of establishing how these fungi gain access to hemoglobin in blood and to other sources of heme remains to be fully addressed. Recent studies are also expanding our knowledge of iron uptake in less-well studied fungal pathogens, including dimorphic fungi where new information reveals an integration of iron acquisition with morphogenesis and cell-surface properties for adhesion to host cells. Overall, the accumulating information provides opportunities to exploit iron acquisition for antifungal therapy, and new work highlights the development of specific inhibitors of siderophore biosynthesis and metal chelators for therapeutic use alone or in conjunction with existing antifungal drugs. It is clear that iron-related therapies will need to be customized for specific diseases because the emerging view is that fungal pathogens use different combinations of strategies for iron acquisition in the varied niches of vertebrate hosts.

Graphical abstract: Iron acquisition in fungal pathogens of humans

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Publication details

The article was received on 27 Dec 2016, accepted on 13 Feb 2017 and first published on 13 Feb 2017


Article type: Minireview
DOI: 10.1039/C6MT00301J
Citation: Metallomics, 2017,9, 215-227
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    Iron acquisition in fungal pathogens of humans

    G. Bairwa, W. Hee Jung and J. W. Kronstad, Metallomics, 2017, 9, 215
    DOI: 10.1039/C6MT00301J

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