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Issue 6, 2017
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Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

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Abstract

The past decade has seen a decided move from static and passive biomaterials to biodegradable, dynamic, and stimuli responsive materials in the laboratory and the clinic. Recent advances towards the rational design of synthetic cell-responsive hydrogels—biomaterials that respond locally to cells or tissues without the input of an artificial stimulus—have provided new strategies and insights on the use of artificial environments for tissue engineering and regenerative medicine. These materials can often approximate responsive functions of a cell's complex natural extracellular environment, and must respond to the small and specific stimuli provided within the vicinity of a cell or tissue. In the current literature, there are three main cell-based stimuli that can be harnessed to create responsive hydrogels: (1) enzymes (2) mechanical force and (3) metabolites/small molecules. Degradable bonds, dynamic covalent bonds, and non-covalent or supramolecular interactions are used to provide responsive architectures that enable features ranging from cell selective infiltration to control of stem-cell differentiation. The growing ability to spatio-temporally control the behavior of cells and tissue with rationally designed responsive materials has the ability to allow control and autonomy to future generations of materials for tissue regeneration, in addition to providing understanding and mimicry of the dynamic and complex cellular niche.

Graphical abstract: Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

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Publication details

The article was received on 29 May 2017, accepted on 31 Aug 2017 and first published on 29 Sep 2017


Article type: Review Article
DOI: 10.1039/C7MH00373K
Citation: Mater. Horiz., 2017,4, 1020-1040
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    Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

    H. W. Ooi, S. Hafeez, C. A. van Blitterswijk, L. Moroni and M. B. Baker, Mater. Horiz., 2017, 4, 1020
    DOI: 10.1039/C7MH00373K

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