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Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

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Abstract

Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host–guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

Graphical abstract: Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

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Publication details

The article was received on 19 Jan 2017, accepted on 22 Mar 2017 and first published on 22 Mar 2017


Article type: Communication
DOI: 10.1039/C7MH00038C
Citation: Mater. Horiz., 2017, Advance Article
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    Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal in vivo imaging

    S. Kim, G. Yun, S. Khan, J. Kim, J. Murray, Y. M. Lee, W. J. Kim, G. Lee, S. Kim, D. Shetty, J. H. Kang, J. Y. Kim, K. M. Park and K. Kim, Mater. Horiz., 2017, Advance Article , DOI: 10.1039/C7MH00038C

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