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Silica-based multifunctional nanodelivery systems toward regenerative medicine


Silica-based nanomaterials (SiNMs) with different forms, including nanoparticles, nanorods and nanofibers either in dense, porous or hollow structure, have been fascinating platforms for the delivery of therapeutic molecules in the inorganic nanocarrier regime. This is primarily due to their unique physicochemical properties that are effective and tunable for the uptake of different cargo molecules as well as to the biological responses favorable for cells and tissues. Over the last decade, substantial studies have exploited SiNMs with different shapes, sizes, mesopore structures, and surface charges for use as cancer therapy, imaging and bioseparation. In particular, the surface is functionalized with candidate molecules from dyes to drugs for theranostic purposes. Moreover, providing the carriers with intelligent modes such as stimuli-responsiveness and with multifunctionality through combining with imaging particles (magnetic nanoparticles, quantum dots and carbon dots) improves the therapeutic and diagnostic potential. This is more impelling that the severe toxicity of the imaging metallic nanoparticles can be reduced by the silica shell. While many pioneering works in the SiNM systems have focused on cancer therapy, there is growing demand on using SiNMs in the areas of regenerative medicine, for stem cell therapy and tracking, and the repair of dysfunctional tissues. Here we review the most recent advances in the SiMNs that are available for the regenerative therapies. For this, we first overview the general nanostructured forms and characteristics of the SiNMs from physicochemical and biological aspects, and then deal with intracellular uptake mechanism and toxicity issue. Finally, advanced designs of the SiNMs to provide multifunctional and intelligent actions of loading and delivery of drugs and molecules are detailed, and then perspectives for the potential uses in regenerative medicine are provided.

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Publication details

The article was received on 08 Jan 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017

Article type: Review Article
DOI: 10.1039/C7MH00017K
Citation: Mater. Horiz., 2017, Accepted Manuscript
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    Silica-based multifunctional nanodelivery systems toward regenerative medicine

    R. Perez, R. Singh, T. Kim and H. Kim, Mater. Horiz., 2017, Accepted Manuscript , DOI: 10.1039/C7MH00017K

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