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A fluorogenic 2D glycosheet for the simultaneous identification of human- and avian-receptor specificity in influenza viruses

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Abstract

The switch in glycan-receptor specificity of influenza viruses may cause their interspecies transmission. However, tools that can simultaneous unveil the different receptor specificities of a single virus strain, in a homogeneous solution, have been elusive. Here we show a simple yet effective “2D glycosheet” that is capable of simultaneously identifying the human- and avian-glycan-receptor specificity of influenza viruses. Two fluorophores with different emission colors are coupled with avian- or human-glycan receptors. Then, the glycan–fluorophore conjugates with different receptors and emission colors are co-assembled on a 2D molybdenum disulfide platform, producing a duplexed, fluorogenic 2D glycosheet. While the system shows a single emission color with viruses containing a single receptor specificity, in the presence of a virus (H7N9) containing dual (human- and avian-) receptor specificity the system produces both emission colors. Interestingly, the use of graphene oxide and carbon nanotubes as the material substrate also produces dual emission with H7N9, thus enabling a new generation of low-dimensional glycomaterials for effectively probing the switch in receptor-specificity of influenza viruses.

Graphical abstract: A fluorogenic 2D glycosheet for the simultaneous identification of human- and avian-receptor specificity in influenza viruses

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Publication details

The article was received on 08 Dec 2016, accepted on 07 Mar 2017, published on 07 Mar 2017 and first published online on 07 Mar 2017


Article type: Communication
DOI: 10.1039/C6MH00571C
Citation: Mater. Horiz., 2017, Advance Article
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    A fluorogenic 2D glycosheet for the simultaneous identification of human- and avian-receptor specificity in influenza viruses

    J. Song, X. Tang, D. Zhou, W. Zhang, T. D. James, X. He and H. Tian, Mater. Horiz., 2017, Advance Article , DOI: 10.1039/C6MH00571C

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