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Issue 4, 2017
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In vitro delivery of calcium ions by nanogated mesoporous silica nanoparticles to induce cancer cellular apoptosis

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Abstract

A pH-operated nanogate on mesoporous silica nanoparticles (MSNs) capable of simultaneous dual-cargo delivery of both metal ions and organic cargo molecules was used to deliver both Hoechst 33342 nuclear stain and calcium ions to MiaPaCa-2 cancer cells. Delivery of calcium to the cell cytoplasm to induce cellular death is an attractive alternative to using traditional, more hazardous chemotherapy drugs. Treatment of cancer cells with Hoechst-loaded, calcium-latched nanogate-modified MSNs resulted in the autonomous release of both cargo types, as visualized by cell nuclei staining and calcium-induced apoptosis. Apoptosis was confirmed by observation of nuclear fragmentation, chromatin condensation, and western blotting for cleaved caspase-3.

Graphical abstract: In vitro delivery of calcium ions by nanogated mesoporous silica nanoparticles to induce cancer cellular apoptosis

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Publication details

The article was received on 10 Jun 2017, accepted on 07 Aug 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7ME00046D
Citation: Mol. Syst. Des. Eng., 2017,2, 384-392
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    In vitro delivery of calcium ions by nanogated mesoporous silica nanoparticles to induce cancer cellular apoptosis

    D. Tarn, C. Yu, J. Lu, A. Hartz, F. Tamanoi and J. I. Zink, Mol. Syst. Des. Eng., 2017, 2, 384
    DOI: 10.1039/C7ME00046D

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