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Issue 3, 2017
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Hydrocyanines: a versatile family of probes for imaging radical oxidants in vitro and in vivo

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Abstract

The hydrocyanines are a class of dyes that can detect reactive oxygen species (ROS) in cell culture, tissue explants, and in vivo. The hydrocyanines selectively react with radical oxidants, such as superoxide via an amine oxidation mechanism to generate cyanine dyes, thereby imaging ROS. The hydrocyanines can detect nanomolar levels of cellular ROS with tunable emission wavelengths between 560–830 nm. The hydrocyanine dyes have excellent stability against auto-oxidation and can be easily synthesized, and this enabled their rapid commercialization. Herein, we discuss in detail the properties of the hydrocyanine dyes and their current applications across biology and medicine.

Graphical abstract: Hydrocyanines: a versatile family of probes for imaging radical oxidants in vitro and in vivo

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Publication details

The article was received on 23 Feb 2017, accepted on 23 May 2017 and first published on 30 May 2017


Article type: Review Article
DOI: 10.1039/C7ME00014F
Citation: Mol. Syst. Des. Eng., 2017,2, 191-200
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    Hydrocyanines: a versatile family of probes for imaging radical oxidants in vitro and in vivo

    C. M. Sadlowski, S. Maity, K. Kundu and N. Murthy, Mol. Syst. Des. Eng., 2017, 2, 191
    DOI: 10.1039/C7ME00014F

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