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Synthesis of biologically active boron-containing compounds

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Abstract

Boron-containing compounds which possess unique and attractive properties have received increasing attention from the pharmaceutical industry and academia recently. They have shown interesting and useful biological activities, including antibacterial, antifungal, antiparasitic, antiviral, and anti-inflammatory activities. In this review, the synthetic strategies for various boron-containing compounds, including peptidyl boronic acids, benzoxaboroles, benzoxaborines, benzodiazaborines, amine carboxyboranes, and amine cyanoboranes are summarized. Representative structures of each structural class and recently developed biologically active boron-containing compounds are used as examples in this review.

Graphical abstract: Synthesis of biologically active boron-containing compounds

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Publication details

The article was received on 31 Oct 2017, accepted on 28 Nov 2017 and first published on 28 Nov 2017


Article type: Review Article
DOI: 10.1039/C7MD00552K
Citation: Med. Chem. Commun., 2018, Advance Article
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    Synthesis of biologically active boron-containing compounds

    F. Yang, M. Zhu, J. Zhang and H. Zhou, Med. Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7MD00552K

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