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Heterocyclic Schiff Base Transition Metal Complexes in Antimicrobial and Anticancer chemotherapy

Abstract

In recent years, the number of people suffering from cancer and multi-resistant infections has sharply increased, leaving the humanity without any choice but to search for new treatment options and strategies. Although cancer is considered the leading cause of death worldwide, it also paves the way for most of the microbial infections and thus increases this burden manifold. Development of small molecules as anti-cancer and anti-microbial agents has a great potential and a plethora of drugs are already available to combat these diseases. However, the wide occurrence of multidrug resistance in both cancer and microbial infections necessitates the development of new and potential molecules with desired properties. A successful strategy in anticancer chemotherapy has been the use of metallo-drugs and this strategy has the potential to be used to treat multi-resistant infections more efficiently. As a class of molecules, Schiff bases have been the topic of considerable interest, owing to their versatile metal chelating properties, inherent biological activities and flexibility to modify the structure to fine tune it for a particular application. Schiff-base based metallo-drugs are being researched to develop new anticancer and anti-microbial chemotherapies and because both anticancer and anti-microbial targets are different, heterocyclic Schiff-bases can be structurally modified to achieve the desired molecule, targeting a particular disease. In this review, we collect the most recent and relevant literature, concerning the synthesis of heterocyclic Schiff-base metal complexes as anticancer and anti-microbial agents and discuss the potential and future of this class of metallo-drugs either as anticancer or anti-microbial agents.

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Publication details

The article was received on 16 Oct 2017, accepted on 05 Dec 2017 and first published on 06 Dec 2017


Article type: Review Article
DOI: 10.1039/C7MD00526A
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
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    Heterocyclic Schiff Base Transition Metal Complexes in Antimicrobial and Anticancer chemotherapy

    M. A. Malik, O. A. Dar, P. GULL, M. Y. Wani and A. A. HAshmi, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00526A

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