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Strigolactones: A plant phytohormone as novel anti-inflammatory agents

Abstract

Strigolactones (SLs) are a novel class of plant hormones with enormous potential in the prevention and treatment of inflammation. To further investigate the anti-inflammatory activities of SLs, a representative SL, GR24 and its reductive products of D-ring were synthesized and their anti-inflammatory activities were fully evaluated on both in vitro and in vivo models. Among these compounds, two most active optical isomers (2a and 6a) demonstrated strong inhibitory activity on the release of inflammatory cytokines including nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) by blocking the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways, as well as greatly inhibited the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae model. These results identified the promising anti-inflammatory effects of SLs, and suggested that both the absolute configuration of SL and the α,β-unsaturated D-ring structure are essential for anti-inflammatory activity.

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Publication details

The article was received on 08 Sep 2017, accepted on 28 Nov 2017 and first published on 05 Dec 2017


Article type: Research Article
DOI: 10.1039/C7MD00461C
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
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    Strigolactones: A plant phytohormone as novel anti-inflammatory agents

    J. Zheng, Y. Han, J. Wang, H. Yang, H. Kong, K. Liu, S. Chen, Y. Chen, Y. Chang, W. Chen, J. Guo and P. Sun, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00461C

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