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Issue 11, 2017
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Cancer nanomedicine: from PDGF targeted drug delivery

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Abstract

An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin (cis-DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future.

Graphical abstract: Cancer nanomedicine: from PDGF targeted drug delivery

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Publication details

The article was received on 31 Jul 2017, accepted on 28 Sep 2017 and first published on 28 Sep 2017


Article type: Research Article
DOI: 10.1039/C7MD00391A
Citation: Med. Chem. Commun., 2017,8, 2055-2059
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    Cancer nanomedicine: from PDGF targeted drug delivery

    C. Rejeeth, R. Vivek, V. NipunBabu, A. Sharma, X. Ding and K. Qian, Med. Chem. Commun., 2017, 8, 2055
    DOI: 10.1039/C7MD00391A

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