Jump to main content
Jump to site search


New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study

Author affiliations

Abstract

The filamenting temperature-sensitive mutant Z (FtsZ) protein is generally recognized as a promising antimicrobial drug target. In the present study, a small organic molecule (tiplaxtinin) was identified for the first time as an excellent cell division inhibitor by using a cell-based screening approach from a library with 250 compounds. Tiplaxtinin possesses potent antibacterial activity against Gram-positive pathogens. Both in vitro and in vivo results reveal that the compound is able to disrupt dynamic assembly of FtsZ and Z-ring formation effectively through the mechanism of stimulating FtsZ polymerization and impairing GTPase activity.

Graphical abstract: New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Jul 2017, accepted on 17 Aug 2017 and first published on 22 Aug 2017


Article type: Research Article
DOI: 10.1039/C7MD00387K
Citation: Med. Chem. Commun., 2017, Advance Article
  •   Request permissions

    New application of tiplaxtinin as an effective FtsZ-targeting chemotype for an antimicrobial study

    N. Sun, Y. Zheng, R. Du, S. Cai, K. Zhang, L. So, K. Cheung, C. Zhuo, Y. Lu and K. Wong, Med. Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7MD00387K

Search articles by author

Spotlight

Advertisements