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Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

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Abstract

ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.

Graphical abstract: Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

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Publication details

The article was received on 21 Jun 2017, accepted on 24 Aug 2017 and first published on 25 Aug 2017


Article type: Research Article
DOI: 10.1039/C7MD00305F
Citation: Med. Chem. Commun., 2017, Advance Article
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    Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer

    L. Luo, Y. Li, Y. Niu, Y. Wang, Q. Wang, X. Fan, J. Xu, L. Liu, E. L. Leung and X. Yao, Med. Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7MD00305F

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