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Synthesis and surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

Abstract

Mesoporous silica-based drug delivery carriers are mostly require an appropriate surface modifications to improve the drug delivery efficiency and to reduce the adverse side effects. In the present work, we have synthesised a mesoporous silica nanoparticles and their surface were covered by using a capping units such as tetrathio-maleimide (TTM) via the “host-guest” complexation mechanism for pH-responsive drug delivery applications. The surface-functionalised melamine (Mela) groups onto the outer surface of the mesoporous silica nanoparticles act as “host” and the surface capped TTM units act as “guest” during the surface capping of the mesoporous silica nanoparticles via the “host-guest” complexation approach. After the encapsulation of cargo into the mesopore channels, the melamine functional groups were covalently immobilised onto the outer surface of the cago loaded MSNs and then the TTM units were introduced onto the outer surface of the silica nanoparticles as a “gatekeeper” to obtained the surface capped mesoporous silica (MSN@Mela@TTM/RhB NPs) to protect the loaded cargo molecules inside the mesopore channels and to prevent from the premature leakage. The surface-capped TTM units were controlled the drug release behavior with respect to the pH of the release medium. In this study, we used rhodamine B (RhB) as model cargo to study the loading and pH-responsive release behavior of the MSN@Mela@TTM NPs. The encapsulated RhB molecules were retained inside the mesopore channels at physiological pH (pH 7.4) condition while an enhanced release were occured at acidic pH (pH 5.0 and 4.0) conditions, respectively. Furthermore, the in vitro biocompatibility and the intracellular uptake efficiency of the synthesised MSNs@Mela@TTM NPs were examined by using MDA-MB-231 cell line. The experimental results suggest that the MSNs@Mela@TTM nanoparticles is biocompatible and could be utilised for pH-stimuli responsive drug delivery applications.

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Publication details

The article was received on 25 May 2017, accepted on 28 Jun 2017 and first published on 13 Jul 2017


Article type: Research Article
DOI: 10.1039/C7MD00270J
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
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    Synthesis and surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

    J. Oh, M. Santha Moorthy, B. Subramaniyan, M. Panchanathan and K. D. Lee, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00270J

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