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Issue 8, 2017
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Extraction of antioxidant and antiproliferative ingredients from fruits of Rubus chingii Hu by active tracking guidance

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Abstract

Rubus chingii Hu, namely “Fu-pen-zi” in Chinese, has been used as a functional food in China for a long time. This study aims to identify its bioactive constituents with antioxidant and anti-tumor properties. R. chingii was extracted with 95% ethanol and then partitioned into four fractions: petroleum ether fraction, ethyl acetate fraction, n-butanol fraction, and water fraction. Results showed that the ethyl acetate fraction had the strongest antioxidant activity and cytotoxicity against human cancer cell lines (HepG-2, Bel-7402, A549 and MCF-7). Therefore, four compounds were isolated from the ethyl acetate fraction, and they were identified as ent-16α,17-dihydroxy-kauran-19-oic acid, tormentic acid, oleanolic acid and β-daucosterol, the first two of which were isolated and identified from R. chingii for the first time. In particular, tormentic acid exhibited excellent cytotoxicity activities against human tumor cell lines. The results obtained in this work might contribute to the understanding of biological activities of R. chingii and further investigation on its potential application is valued for food and drugs.

Graphical abstract: Extraction of antioxidant and antiproliferative ingredients from fruits of Rubus chingii Hu by active tracking guidance

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Publication details

The article was received on 10 May 2017, accepted on 24 Jun 2017 and first published on 28 Jun 2017


Article type: Research Article
DOI: 10.1039/C7MD00240H
Citation: Med. Chem. Commun., 2017,8, 1673-1680
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    Extraction of antioxidant and antiproliferative ingredients from fruits of Rubus chingii Hu by active tracking guidance

    T. Zhang, Y. Liu, L. Yang, J. Jiang, J. Zhao and W. Zhu, Med. Chem. Commun., 2017, 8, 1673
    DOI: 10.1039/C7MD00240H

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