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18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway

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Abstract

Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB in the LPS-stimulated RAW264.7 cells. Further in vivo results showed that 18α-GAMG could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.

Graphical abstract: 18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway

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Publication details

The article was received on 26 Apr 2017, accepted on 28 May 2017 and first published on 02 Jun 2017


Article type: Research Article
DOI: 10.1039/C7MD00210F
Citation: Med. Chem. Commun., 2017, Advance Article
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    18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway

    B. Li, Y. Yang, L. Chen, S. Chen, J. Zhang and W. Tang, Med. Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7MD00210F

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