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Peptide-fluorophore/AuNP conjugate-based two-photon excited fluorescent nanosensor for caspase-3 activity imaging assay in living cells and tissue

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Abstract

In the present study, a novel fluorescence resonance energy transfer (FRET) strategy-based two-photon excited nanosensor via the assembly of two-photon dye-labeled peptides on the gold nanoparticle's surface has been developed and successfully applied in the caspase-3 imaging assay in living cells and ischemia–reperfusion surgery-treated rat liver tissue slices.

Graphical abstract: Peptide-fluorophore/AuNP conjugate-based two-photon excited fluorescent nanosensor for caspase-3 activity imaging assay in living cells and tissue

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Publication details

The article was received on 11 Apr 2017, accepted on 11 May 2017 and first published on 12 May 2017


Article type: Research Article
DOI: 10.1039/C7MD00177K
Citation: Med. Chem. Commun., 2017, Advance Article
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    Peptide-fluorophore/AuNP conjugate-based two-photon excited fluorescent nanosensor for caspase-3 activity imaging assay in living cells and tissue

    Q. Ge, N. Wang, J. Li and R. Yang, Med. Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7MD00177K

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