Jump to main content
Jump to site search


Synthesis, Molecular Modeling and Biological Evaluation of Aza-flavanones as α-Glucosidase Inhibitors

Abstract

An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their α-glucosidase inhibitory activity is evaluated using Acarbose, Miglitol and Voglibose as reference standards. And also molecular modeling studies were performed for all compounds to identify important binding modes responsible for inhibition activity of α-glucosidase which helped to find key interactions between the enzyme and the active compounds. Among all the compounds 5g, 5r and 5w have shown high α–glucosidase inhibition activity compared to standard reference drugs and identified as promising potential antidiabetic agents. It is the first biological evaluation of aza-flavanones as α-glucosidase inhibitors.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Apr 2017, accepted on 08 Jun 2017 and first published on 14 Jun 2017


Article type: Research Article
DOI: 10.1039/C7MD00162B
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
  •   Request permissions

    Synthesis, Molecular Modeling and Biological Evaluation of Aza-flavanones as α-Glucosidase Inhibitors

    S. Kasturi, S. Surarapu, C. C. Bathoju, S. Uppalanchi, S. Dwivedi, Y. Perumal , D. K. Sigalapalli , N. B. Bathini, K. S. Ethiraj and J. Anireddy, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00162B

Search articles by author

Spotlight

Advertisements