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Applications and Perspectives of Nanomaterials in Novel Vaccine Development

Abstract

Vaccines show great potentials for both prophylactic and therapeutic use in infections, cancer, and other diseases.With the rapid development of bio-technologies and material sciences,Nanomaterials are playing essential roles in novel vaccine formulations and can boost antigen effectiveness by operating as a delivery system to enhance antigen processing and/or as immune-potentiating adjuvants to induce or potentiate immune responses. The effect of nanoparticles in the vaccinology showed enhanced antigen stability and immunogenicity as well as targeted delivery and slow release. However, obstacles remain for the lack of fundamental knowledge on the detailed molecular working mechanism and in vivo bio-effect of nanoparticles. This review provides a broad overview of the current improvement in nanoparticles in vaccinology. Modern nanoparticle vaccines are classified by nanoparticles action into those based on either delivery system or immune potentiator approaches. The mechanism of interaction of nanoparticles with the antigens and immune systems are discussed. Nanoparticle vaccines that have been approved for use are also listed. The fundamental understanding of in vivo biodistribution and the fate of nanoparticles will accelerate the rational design of new nanoparticles comprising vaccines in the future.

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Publication details

The article was received on 31 Mar 2017, accepted on 17 Oct 2017 and first published on 17 Oct 2017


Article type: Review Article
DOI: 10.1039/C7MD00158D
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
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    Applications and Perspectives of Nanomaterials in Novel Vaccine Development

    Y. Shen, T. Hao, S. Ou, C. Hu and L. Chen, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00158D

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