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Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids at FFA1, FFA4 and GPR84

Abstract

Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results reveal that the introduction of a hydroxy group and its position has high impact on receptor activity.

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Publication details

The article was received on 14 Mar 2017, accepted on 08 May 2017 and first published on 12 May 2017


Article type: Research Article
DOI: 10.1039/C7MD00130D
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
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    Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids at FFA1, FFA4 and GPR84

    M. H. Kaspersen, L. Jenkins, J. Dunlop, G. Milligan and T. Ulven, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00130D

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