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Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

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Abstract

The soluble mycobacterial carbonic anhydrases Rv3588c and Rv1284 belong to a different class of carbonic anhydrases than those found in humans, making them attractive drug targets by using the inherent differences in the folds of the different classes. By screening a natural product library, we identified naphthoquinone derivatives as a novel non-classical inhibitor scaffold of mycobacterial carbonic anhydrases that lack the sulfonamide/sulfamate group and thus did not affect human carbonic anhydrase II.

Graphical abstract: Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

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Publication details

The article was received on 22 Feb 2017, accepted on 08 May 2017 and first published on 12 May 2017


Article type: Research Article
DOI: 10.1039/C7MD00090A
Citation: Med. Chem. Commun., 2017, Advance Article
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    Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c

    M. A. Dallaston, S. Rajan, J. Chekaiban, M. Wibowo, M. Cross, M. J. Coster, R. A. Davis and A. Hofmann, Med. Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7MD00090A

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