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Issue 9, 2017
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Imidazoles as potential anticancer agents

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Cancer is a black spot on the face of humanity in this era of science and technology. Presently, several classes of anticancer drugs are available in the market, but issues such as toxicity, low efficacy and solubility have decreased the overall therapeutic indices. Thus, the search for new promising anticancer agents continues, and the battle against cancer is far from over. Imidazole is an aromatic diazole and alkaloid with anticancer properties. There is considerable interest among scientists in developing imidazoles as safe alternatives to anticancer chemotherapy. The present article describes the structural, chemical, and biological features of imidazoles. Several classes of imidazoles as anticancer agents based on their mode of action have been critically discussed. A careful observation has been made into pharmacologically active imidazoles with better or equal therapeutic effects compared to well-known imidazole-based anticancer drugs, which are available on the market. A brief discussion of the toxicities of imidazoles has been made. Finally, the current challenges and future perspectives of imidazole based anticancer drug development are conferred.

Graphical abstract: Imidazoles as potential anticancer agents

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Publication details

The article was received on 07 Feb 2017, accepted on 21 Mar 2017 and first published on 13 Apr 2017

Article type: Review Article
DOI: 10.1039/C7MD00067G
Citation: Med. Chem. Commun., 2017,8, 1742-1773
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    Imidazoles as potential anticancer agents

    I. Ali, M. N. Lone and H. Y. Aboul-Enein, Med. Chem. Commun., 2017, 8, 1742
    DOI: 10.1039/C7MD00067G

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