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Recent Progress in the Development of Metal Complexes as β-Amyloid Imaging Probes in the Brain

Abstract

In this review, we have focused on the recent progress in metal complexes that are able to bind to β-amyloid (Aβ) species. We have discussed various radioactive complexes of 99mTc, 68Ga, 64Cu, 89Zr, and 111In, which were designed as Aβ imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, non-radioactive Re and Ru complexes as for Aβ sensors using luminescence methods, and Gd3+ complexes as contrast agents for magnetic resonance imaging (MRI).

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Publication details

The article was received on 05 Feb 2017, accepted on 11 May 2017 and first published on 16 May 2017


Article type: Review Article
DOI: 10.1039/C7MD00064B
Citation: Med. Chem. Commun., 2017, Accepted Manuscript
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    Recent Progress in the Development of Metal Complexes as β-Amyloid Imaging Probes in the Brain

    K. Chen and M. Cui, Med. Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7MD00064B

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