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Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

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Abstract

A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and then fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.

Graphical abstract: Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

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Publication details

The article was received on 05 Jan 2017, accepted on 07 Mar 2017 and first published on 10 Mar 2017


Article type: Research Article
DOI: 10.1039/C7MD00008A
Citation: Med. Chem. Commun., 2017, Advance Article
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    Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

    E. O. J. Porta, S. N. Jäger, I. Nocito, G. I. Lepesheva, E. C. Serra, B. L. Tekwani and G. R. Labadie, Med. Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7MD00008A

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