Jump to main content
Jump to site search

Issue 5, 2017
Previous Article Next Article

Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

Author affiliations

Abstract

Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (−)-borneol and (−)-isoborneol as potent inhibitors of the influenza A virus. All compounds were tested for their toxicity against MDCK cells and for virus-inhibiting activity against the influenza virus A/Puerto Rico/8/34 (H1N1). Compounds 7, 16 and 26 containing a morpholine fragment exhibited the highest efficiency as agents inhibiting the replication of the influenza virus A(H1N1) with selectivity indices of 82, 45 and 65, correspondingly. Derivatives 9 (SI = 23) and 18 (SI = 25) containing a 1-methylpiperazine motif showed moderate antiviral activity. Structure–activity analysis of this new series of borneol derivatives revealed that a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold is required for the antiviral activity.

Graphical abstract: Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 28 Nov 2016, accepted on 28 Feb 2017 and first published on 03 Mar 2017


Article type: Research Article
DOI: 10.1039/C6MD00657D
Citation: Med. Chem. Commun., 2017,8, 960-963
  •   Request permissions

    Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

    A. S. Sokolova, O. I. Yarovaya, M. D. Semenova, A. A. Shtro, I. R. Orshanskaya, V. V. Zarubaev and N. F. Salakhutdinov, Med. Chem. Commun., 2017, 8, 960
    DOI: 10.1039/C6MD00657D

Search articles by author