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Issue 5, 2017
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Exploring the links between peptoid antibacterial activity and toxicity

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Abstract

Peptoids are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicity data is somewhat limited and as such rationally designing effective antimicrobial peptoids can be challenging. Herein, we present the toxicity profiling of a series of linear peptoids against mammalian cell lines (HaCaT and HepG2). The cytotoxicity of the peptoid library has then been correlated with their antibacterial properties against Gram-positive and Gram-negative bacteria and also to the hydrophobicity of the peptoid sequences. The work presented provides valuable data to aid in the future rational design of antimicrobial peptoids.

Graphical abstract: Exploring the links between peptoid antibacterial activity and toxicity

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Publication details

The article was received on 22 Nov 2016, accepted on 27 Jan 2017 and first published on 01 Feb 2017


Article type: Research Article
DOI: 10.1039/C6MD00648E
Citation: Med. Chem. Commun., 2017,8, 886-896
  • Open access: Creative Commons BY license
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    Exploring the links between peptoid antibacterial activity and toxicity

    H. L. Bolt, G. A. Eggimann, C. A. B. Jahoda, R. N. Zuckermann, G. J. Sharples and S. L. Cobb, Med. Chem. Commun., 2017, 8, 886
    DOI: 10.1039/C6MD00648E

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