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Issue 3, 2017
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Synthesis and antitumor mechanism of a new iron(III) complex with 5,7-dichloro-2-methyl-8-quinolinol as ligands

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Abstract

A new iron(III) complex with 5,7-dichloro-2-methyl-8-quinolinol (HClMQ) as ligands, i.e., [Fe(ClMQ)2Cl] (1), was synthesized and evaluated for its anticancer activity. Compared to the HClMQ ligand, complex 1 showed a higher cytotoxicity towards a series of tumor cell lines, including Hep-G2, BEL-7404, NCI-H460, A549, and T-24, with IC50 values in the range of 5.04–14.35 μM. Notably, the Hep-G2 cell line was the most sensitive to complex 1. Mechanistic studies indicated that complex 1 is a telomerase inhibitor targeting c-myc G-quadruplex DNA and can trigger cell apoptosis via inducing cell cycle arrest and DNA damage.

Graphical abstract: Synthesis and antitumor mechanism of a new iron(iii) complex with 5,7-dichloro-2-methyl-8-quinolinol as ligands

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Publication details

The article was received on 20 Nov 2016, accepted on 26 Jan 2017 and first published on 01 Feb 2017


Article type: Research Article
DOI: 10.1039/C6MD00644B
Citation: Med. Chem. Commun., 2017,8, 633-639
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    Synthesis and antitumor mechanism of a new iron(III) complex with 5,7-dichloro-2-methyl-8-quinolinol as ligands

    B. Zou, Q. Qin, Y. Bai, Q. Cao, Y. Zhang, Y. Liu, Z. Chen and H. Liang, Med. Chem. Commun., 2017, 8, 633
    DOI: 10.1039/C6MD00644B

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