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Issue 3, 2017
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Recent advances in the medicinal chemistry of group II and group III mGlu receptors

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Abstract

Metabotropic glutamate receptors (mGlu receptors) belong to the G-protein-coupled receptors superfamily. They are divided into three groups, in which group II and group III belong to presynaptic receptors that negatively modulate glutamate and γ-aminobutyric acid (GABA) release when activated. In this review, we introduce not only the functions of mGlu receptors, but also the group II and group III allosteric modulators and agonists/antagonists reported over the past five years according to a classification of their structures, with a specific focus on their biological activity and selectivity. In particular, the structure of these compounds and the future directions of ideal candidates are highlighted.

Graphical abstract: Recent advances in the medicinal chemistry of group II and group III mGlu receptors

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Publication details

The article was received on 04 Nov 2016, accepted on 03 Jan 2017 and first published on 13 Jan 2017


Article type: Review Article
DOI: 10.1039/C6MD00612D
Citation: Med. Chem. Commun., 2017,8, 501-515
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    Recent advances in the medicinal chemistry of group II and group III mGlu receptors

    C. Jin and S. Ma, Med. Chem. Commun., 2017, 8, 501
    DOI: 10.1039/C6MD00612D

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