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Host immune evasion strategies of malaria blood stage parasite

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Abstract

Host immune evasion is a key strategy for the continual survival of many microbial pathogens including Apicomplexan protozoan: Plasmodium spp., the causative agent of Malaria. The malaria parasite has evolved a variety of mechanisms to evade the host immune responses within its two hosts: the female Anopheles mosquito vector and vertebrate host. In this review, we will focus on the molecular mechanisms of the immune evasion strategies used by the Plasmodium parasite at the blood stage which is responsible for the clinical manifestations of human malaria. We also aim to provide some insights on the potential targets for malaria interventions through the recent advancement in understanding the molecular biology of the parasite.

Graphical abstract: Host immune evasion strategies of malaria blood stage parasite

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Publication details

The article was received on 11 Aug 2017, accepted on 23 Oct 2017 and first published on 23 Oct 2017


Article type: Review Article
DOI: 10.1039/C7MB00502D
Citation: Mol. BioSyst., 2017, Advance Article
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    Host immune evasion strategies of malaria blood stage parasite

    X. Y. Yam and P. R. Preiser, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00502D

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