Jump to main content
Jump to site search


Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library

Author affiliations

Abstract

Mannose-modified lectin-binding peptides were obtained from an α-helical-designed peptide phage library. Concanavalin A (ConA) was used as a representative target protein for the lectin family. The identified glycopeptides could selectively bind to ConA with micromolar affinity. With these results, the methodologies described in this study will enhance the selection of saccharide-modified ligands through the synergistic effects of sugar and peptide units, with better specificity and affinity towards lectin proteins.

Graphical abstract: Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Aug 2017, accepted on 13 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7MB00495H
Citation: Mol. BioSyst., 2017, Advance Article
  •   Request permissions

    Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library

    I. Ven Chang, H. Tsutsumi and H. Mihara, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00495H

Search articles by author

Spotlight

Advertisements