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Issue 11, 2017
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Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library

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Abstract

Mannose-modified lectin-binding peptides were obtained from an α-helical-designed peptide phage library. Concanavalin A (ConA) was used as a representative target protein for the lectin family. The identified glycopeptides could selectively bind to ConA with micromolar affinity. With these results, the methodologies described in this study will enhance the selection of saccharide-modified ligands through the synergistic effects of sugar and peptide units, with better specificity and affinity towards lectin proteins.

Graphical abstract: Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library

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Publication details

The article was received on 09 Aug 2017, accepted on 13 Sep 2017 and first published on 13 Sep 2017


Article type: Communication
DOI: 10.1039/C7MB00495H
Citation: Mol. BioSyst., 2017,13, 2222-2225
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    Screening for concanavalin A binders from a mannose-modified α-helix peptide phage library

    I. Ven Chang, H. Tsutsumi and H. Mihara, Mol. BioSyst., 2017, 13, 2222
    DOI: 10.1039/C7MB00495H

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