Jump to main content
Jump to site search


Methods for monitoring and measurement of protein translation in time and space

Author affiliations

Abstract

Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison to transcriptional regulation, however, translational control has remained a significantly under-studied layer of gene expression. This trend is now beginning to shift thanks to recent advances in next-generation sequencing, proteomics, and microscopy based methodologies which allow accurate monitoring of protein translation rates, from single target messenger RNA molecules to genome-wide scale studies. In this review, we summarize these recent advances, and discuss how they are enabling researchers to study translational regulation in a wide variety of in vitro and in vivo biological systems, with unprecedented depth and spatiotemporal resolution.

Graphical abstract: Methods for monitoring and measurement of protein translation in time and space

Back to tab navigation

Publication details

The article was received on 31 Jul 2017, accepted on 12 Oct 2017 and first published on 12 Oct 2017


Article type: Review Article
DOI: 10.1039/C7MB00476A
Citation: Mol. BioSyst., 2017, Advance Article
  •   Request permissions

    Methods for monitoring and measurement of protein translation in time and space

    M. Dermit, M. Dodel and F. K. Mardakheh, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00476A

Search articles by author

Spotlight

Advertisements