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Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes

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Abstract

Changes of the extracellular milieu could affect cellular crowding. To prevent detrimental effects, cells use adaptation mechanisms to react to such conditions. Using fluorescent crowding sensors, we show that the initial response to osmotic stress is fast but imperfect, while the slow response renders cells more tolerant to stress, particularly in the presence of osmolytes.

Graphical abstract: Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes

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Publication details

The article was received on 17 Jul 2017, accepted on 14 Sep 2017 and first published on 14 Sep 2017


Article type: Communication
DOI: 10.1039/C7MB00432J
Citation: Mol. BioSyst., 2017, Advance Article
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    Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes

    D. Gnutt, O. Brylski, E. Edengeiser, M. Havenith and S. Ebbinghaus, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00432J

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