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Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death

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Abstract

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H2S donor micelle releases H2S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.

Graphical abstract: Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death

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Publication details

The article was received on 30 Mar 2017, accepted on 23 Jun 2017 and first published on 28 Jun 2017


Article type: Communication
DOI: 10.1039/C7MB00191F
Citation: Mol. BioSyst., 2017, Advance Article
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    Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death

    T. Takatani-Nakase, M. Katayama, C. Matsui, K. Hanaoka, A. J. van der Vlies, K. Takahashi, I. Nakase and U. Hasegawa, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00191F

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