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Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein

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Abstract

The ability to modulate angiogenesis by chemical tools has several important applications in different scientific fields. With the perspective of finding novel proangiogenic molecules, we searched peptide sequences with a chemical profile similar to that of the QK peptide, a well described VEGF mimetic peptide. We found that residues 1617–1627 of the IQGAP1 protein show molecular features similar to those of the QK peptide sequence. The IQGAP1-derived synthetic peptide was analyzed by NMR spectroscopy and its biological activity was characterized in endothelial cells. These studies showed that this IQGAP1-derived peptide has a biological activity similar to that of VEGF and could be considered as a novel tool for reparative angiogenesis.

Graphical abstract: Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein

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Publication details

The article was received on 30 Mar 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017


Article type: Paper
DOI: 10.1039/C7MB00190H
Citation: Mol. BioSyst., 2017, Advance Article
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    Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein

    D. Capasso, S. Di Gaetano, V. Celentano, D. Diana, L. Festa, R. Di Stasi, L. De Rosa, R. Fattorusso and L. D. D'Andrea, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00190H

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