Issue 8, 2017

Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein

Abstract

The ability to modulate angiogenesis by chemical tools has several important applications in different scientific fields. With the perspective of finding novel proangiogenic molecules, we searched peptide sequences with a chemical profile similar to that of the QK peptide, a well described VEGF mimetic peptide. We found that residues 1617–1627 of the IQGAP1 protein show molecular features similar to those of the QK peptide sequence. The IQGAP1-derived synthetic peptide was analyzed by NMR spectroscopy and its biological activity was characterized in endothelial cells. These studies showed that this IQGAP1-derived peptide has a biological activity similar to that of VEGF and could be considered as a novel tool for reparative angiogenesis.

Graphical abstract: Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein

Supplementary files

Article information

Article type
Paper
Submitted
30 Mar 2017
Accepted
12 Jun 2017
First published
12 Jun 2017

Mol. BioSyst., 2017,13, 1619-1629

Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein

D. Capasso, S. Di Gaetano, V. Celentano, D. Diana, L. Festa, R. Di Stasi, L. De Rosa, R. Fattorusso and L. D. D'Andrea, Mol. BioSyst., 2017, 13, 1619 DOI: 10.1039/C7MB00190H

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