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Anticancer effects of novel resveratrol analogues on human ovarian cancer cells

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Abstract

Resveratrol, a naturally occurring phytoalexin, has long been known to play an important regulatory role in key functions in cell physiology. This multifunctional role of resveratrol is explained by its ability to interact with several targets of various cell pathways. In the recent past, synthetic chemical modifications have been made in an attempt to enhance the biological effects of resveratrol, including its anti-cancer properties. In this study, we investigated the molecular mechanisms of action of novel trans-restricted analogues of resveratrol in which the C–C double bond of the natural derivative has been replaced by diaryl-substituted imidazole analogues. In ovarian cancer models, the results of in vitro screening revealed that the resveratrol analogues exhibited enhanced anti-proliferative properties compared with resveratrol. We found that the resveratrol analogues also significantly inhibited Akt and MAPK signalling and reduced the migration of IL-6 and EGF-treated cells. Finally, in ascite-derived cancer cells, we demonstrated that the resveratrol analogues reduced the expression of epithelial mesenchymal transition (EMT) markers. Collectively, these findings indicate the enhanced anti-cancer properties of the resveratrol analogues.

Graphical abstract: Anticancer effects of novel resveratrol analogues on human ovarian cancer cells

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Publication details

The article was received on 02 Mar 2017, accepted on 02 Apr 2017 and first published on 06 Apr 2017


Article type: Paper
DOI: 10.1039/C7MB00128B
Citation: Mol. BioSyst., 2017, Advance Article
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    Anticancer effects of novel resveratrol analogues on human ovarian cancer cells

    D. Vergara, S. De Domenico, A. Tinelli, E. Stanca, L. L. Del Mercato, A. M. Giudetti, P. Simeone, N. Guazzelli, M. Lessi, C. Manzini, A. Santino, F. Bellina and M. Maffia, Mol. BioSyst., 2017, Advance Article , DOI: 10.1039/C7MB00128B

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