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Towards microwave imaging of cells

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Abstract

Integrated detection techniques that can characterize the morphological properties of cells are needed for the widespread use of lab-on-a-chip technology. Herein, we establish a theoretical and experimental framework to use resonant microwave sensors in their higher order modes so that the morphological properties of analytes inside a microfluidic channel can be obtained electronically. We built a phase-locked loop system that can track the first two modes of a microstrip line resonator to detect the size and location of microdroplets and cells passing through embedded microfluidic channels. The attained resolution, expressed in terms of Allan deviation at the response time, is as small as 2 × 10−8 for both modes. Additionally, simulations were performed to show that sensing with higher order modes can yield the geometrical volume, effective permittivity, two-dimensional extent, and the orientation of analytes. The framework presented here makes it possible to develop a novel type of microscope that operates at the microwave band, i.e., a radar for cells.

Graphical abstract: Towards microwave imaging of cells

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Publication details

The article was received on 23 Nov 2017, accepted on 04 Dec 2017 and first published on 06 Dec 2017


Article type: Paper
DOI: 10.1039/C7LC01251A
Citation: Lab Chip, 2018, Advance Article
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    Towards microwave imaging of cells

    M. Kelleci, H. Aydogmus, L. Aslanbas, S. O. Erbil and M. S. Hanay, Lab Chip, 2018, Advance Article , DOI: 10.1039/C7LC01251A

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