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Electrochemical biosensor for cancer cell detection based on surface 3D micro-array


The detection of rare circulating tumour cells (CTCs) in the patients’ blood is crucial for the early diagnosis of cancer, highly precise cancer therapy and monitoring the therapeutic outcomes in real time. In this study, we have developed an efficient strategy to capture and detect CTCs from the blood of cancer patients using benzoboric acid modified gold-plated polymeric substrate with regular 3D surface array. Compared with the smooth substrate, the substrate with surface 3D microarrays we prepared exhibits exhibited higher capture efficiency, i. e. 2-foldalmost double of that the efficiency afforded by the smooth substrate. Additionaly, Due due to the reversible reaction between the benzoboric acid on 3D microarray and the sialic acid on CTCs, our strategy allows allowed for easy detachment of the captured CTCs from the substrate without causing critical damage to cell. It will benefit for the gaining further access to these rare cells in sample for downstream characterization. The proposed strategy we report here provides several advantages, including enhanced capture efficiency, high sensitivity, low cost and recovery of isolated CTCs, and could become a promising platform for the early stage diagnosis of cancer.

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Publication details

The article was received on 16 Oct 2017, accepted on 06 Dec 2017 and first published on 06 Dec 2017

Article type: Paper
DOI: 10.1039/C7LC01117B
Citation: Lab Chip, 2017, Accepted Manuscript
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    Electrochemical biosensor for cancer cell detection based on surface 3D micro-array

    S. Liu, L. An, G. Wang, Y. Han, T. Li and P. Jin, Lab Chip, 2017, Accepted Manuscript , DOI: 10.1039/C7LC01117B

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