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On-demand acoustic droplet splitting and steering in a disposable microfluidic chip

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Abstract

On-chip droplet splitting is one of the fundamental droplet-based microfluidic unit operations to control droplet volume after production and increase operational capability, flexibility, and throughput. Various droplet splitting methods have been proposed, and among them the acoustic droplet splitting method is promising because of its label-free operation without any physical or thermal damage to droplets. Previous acoustic droplet splitting methods faced several limitations: first, they employed a cross-type acoustofluidic device that precluded multichannel droplet splitting; second, they required irreversible bonding between a piezoelectric substrate and a microfluidic chip, such that the fluidic chip was not replaceable. Here, we present a parallel-type acoustofluidic device with a disposable microfluidic chip to address the limitations of previous acoustic droplet splitting devices. In the proposed device, an acoustic field is applied in the direction opposite to the flow direction to achieve multichannel droplet splitting and steering. A disposable polydimethylsiloxane microfluidic chip is employed in the developed device, thereby removing the need for permanent bonding and improving the flexibility of the droplet microfluidic device. We experimentally demonstrated on-demand acoustic droplet bi-splitting and steering with precise control over the droplet splitting ratio, and we investigated the underlying physical mechanisms of droplet splitting and steering based on Laplace pressure and ray acoustics analyses, respectively. We also demonstrated droplet tri-splitting to prove the feasibility of multichannel droplet splitting. The proposed on-demand acoustic droplet splitting device enables on-chip droplet volume control in various droplet-based microfluidic applications.

Graphical abstract: On-demand acoustic droplet splitting and steering in a disposable microfluidic chip

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Publication details

The article was received on 09 Oct 2017, accepted on 29 Nov 2017 and first published on 30 Nov 2017


Article type: Paper
DOI: 10.1039/C7LC01083D
Citation: Lab Chip, 2018, Advance Article
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    On-demand acoustic droplet splitting and steering in a disposable microfluidic chip

    J. Park, J. H. Jung, K. Park, G. Destgeer, H. Ahmed, R. Ahmad and H. J. Sung, Lab Chip, 2018, Advance Article , DOI: 10.1039/C7LC01083D

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