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Issue 23, 2017
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Integrated microHall magnetometer to measure the magnetic properties of nanoparticles

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Abstract

Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation. By applying the iHM, we demonstrate versatile magnetic assays. We measured the magnetic susceptibility and moments of MNPs using small sample amounts (∼10 pL), identified different MNP compositions in mixtures, and detected MNP-labeled single cells.

Graphical abstract: Integrated microHall magnetometer to measure the magnetic properties of nanoparticles

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Publication details

The article was received on 31 Aug 2017, accepted on 19 Oct 2017 and first published on 19 Oct 2017


Article type: Communication
DOI: 10.1039/C7LC00934H
Citation: Lab Chip, 2017,17, 4000-4007
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    Integrated microHall magnetometer to measure the magnetic properties of nanoparticles

    C. Min, J. Park, J. K. Mun, Y. Lim, J. Min, J. Lim, D. Kang, H. Ahn, T. Shin, J. Cheon, H. Lee, R. Weissleder, C. M. Castro and H. Lee, Lab Chip, 2017, 17, 4000
    DOI: 10.1039/C7LC00934H

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