Jump to main content
Jump to site search


On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules

Author affiliations

Abstract

Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing steps that render the process repetitive and time-consuming. Here, ferrofluid droplets were explored for this purpose as an elegant alternative of templates that can be easily manipulated via an external magnetic field, and require only a simple microfluidic chip design and setup. Glass microfluidic devices featuring T-junctions or flow focusing junctions for the generation of oil-based ferrofluid droplets in an aqueous continuous phase were investigated. Droplet size was controlled by the microfluidic channel dimensions as well as the flow rates of the ferrofluid and aqueous phases. The generated droplets were stabilised by a surface active polymer, polyvinylpyrrolidone (PVP), and then guided into a chamber featuring alternating, co-laminar PE solutions and wash streams, and deflected across them by means of an external permanent magnet. The extent of droplet deflection was tailored by the flow rates, the concentration of magnetic nanoparticles in the droplets, and the magnetic field strength. PVP-coated ferrofluid droplets were deflected through solutions of polyelectrolyte and washing streams using several iterations of multilaminar flow designs. This culminated in an innovative “Snakes-and-Ladders” inspired microfluidic chip design that overcame various issues of the previous iterations for the deposition of layers of anionic poly(sodium-4-styrene sulfonate) (PSS) and cationic poly(fluorescein isothiocyanate allylamine hydrochloride) (PAH-FITC) onto the droplets. The presented method demonstrates a simple and rapid process for PE layer deposition in <30 seconds, and opens the way towards rapid layer-by-layer assembly of PE microcapsules for drug delivery applications.

Graphical abstract: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Aug 2017, accepted on 02 Oct 2017 and first published on 02 Oct 2017


Article type: Paper
DOI: 10.1039/C7LC00918F
Citation: Lab Chip, 2017, Advance Article
  •   Request permissions

    On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules

    A. Q. Alorabi, M. D. Tarn, J. Gómez-Pastora, E. Bringas, I. Ortiz, V. N. Paunov and N. Pamme, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00918F

Search articles by author

Spotlight

Advertisements