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Staggered trap arrays for robust microfluidic sample digitization

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Abstract

A sample digitization method that exploits the controlled pinning of fluid at geometric discontinuities within an array of staggered microfluidic traps is presented. The staggered trap design enables reliable sample filling within high aspect ratio microwells, even when employing substrate materials such as thermoplastics that are not gas permeable. A simple geometric model is developed to predict the impact of device geometry on sample filling and discretization, and validated experimentally using fabricated cyclic olefin polymer devices. Using the developed design guidelines, a 768-element staggered trap array is demonstrated, with reliable passive loading and discretization achieved within 5 min. The resulting discretization platform offers a simplified workflow with flexible trap design, reliable discretization, and repeatable operation using low-cost thermoplastic substrates.

Graphical abstract: Staggered trap arrays for robust microfluidic sample digitization

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Publication details

The article was received on 08 Aug 2017, accepted on 23 Oct 2017 and first published on 24 Oct 2017


Article type: Paper
DOI: 10.1039/C7LC00846E
Citation: Lab Chip, 2017, Advance Article
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    Staggered trap arrays for robust microfluidic sample digitization

    A. J. Sposito and D. L. DeVoe, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00846E

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