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An acoustic on-chip goniometer for room temperature macromolecular crystallography

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Abstract

This paper describes the design, development and successful use of an on-chip goniometer for room-temperature macromolecular crystallography via acoustically induced rotations. We present for the first time a low cost, rate-tunable, acoustic actuator for gradual in-fluid sample reorientation about varying axes and its utilisation for protein structure determination on a synchrotron beamline. The device enables the efficient collection of diffraction data via a rotation method from a sample within a surface confined droplet. This method facilitates efficient macromolecular structural data acquisition in fluid environments for dynamical studies.

Graphical abstract: An acoustic on-chip goniometer for room temperature macromolecular crystallography

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Publication details

The article was received on 01 Aug 2017, accepted on 01 Nov 2017 and first published on 01 Nov 2017


Article type: Communication
DOI: 10.1039/C7LC00812K
Citation: Lab Chip, 2017, Advance Article
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    An acoustic on-chip goniometer for room temperature macromolecular crystallography

    C. G. Burton, D. Axford, A. M. J. Edwards, R. J. Gildea, R. H. Morris, M. I. Newton, A. M. Orville, M. Prince, P. D. Topham and P. T. Docker, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00812K

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