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Issue 21, 2017
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Spiral microchannel with ordered micro-obstacles for continuous and highly-efficient particle separation

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Abstract

Controllable manipulation of fluid flow is crucial for efficient particle separation, which is associated with plenty of biomedical and industrial applications. Microfluidic technologies have achieved promising progress in particle positioning depending on inertial force with or without the help of the Dean effect. Herein, we describe an inertial microfluidic system containing a spiral microchannel for various highly efficient particle separations. We demonstrated that Dean-like secondary flow can be regulated by geometric confinement in the microchannel. On the introduction of a library of micro-obstacles into the spiral microchannels, the resulting linear acceleration of secondary flow can be applied to remarkably enhance particle focusing in time and space. Further, multiple separating and sorting manipulations of particles including polymeric particles, circulating tumor cells, and blood cells, can be successfully accomplished in the dimension-confined spiral channels in a sheathless, high-throughput (typically 3 ml min−1), long-term (at least 4 h), and highly-efficient (up to 99.8% focusing) manner. The methodological achievement pointing to ease-of-use, effective, and high-throughput particle manipulations is useful for both laboratory and commercial developments of microfluidic systems in life and material sciences.

Graphical abstract: Spiral microchannel with ordered micro-obstacles for continuous and highly-efficient particle separation

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Publication details

The article was received on 03 Jul 2017, accepted on 21 Sep 2017 and first published on 27 Sep 2017


Article type: Paper
DOI: 10.1039/C7LC00691H
Citation: Lab Chip, 2017,17, 3578-3591
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    Spiral microchannel with ordered micro-obstacles for continuous and highly-efficient particle separation

    S. Shen, C. Tian, T. Li, J. Xu, S. Chen, Q. Tu, M. Yuan, W. Liu and J. Wang, Lab Chip, 2017, 17, 3578
    DOI: 10.1039/C7LC00691H

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