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Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles

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Abstract

The microfluidic passive control of microparticles largely relies on the hydrodynamic effects of the carrier media such as Newtonian fluids and viscoelastic fluids. Yet the viscoelastic/Newtonian interfacial effect has been scarcely investigated, especially for high-resolution particle separation. Here we report a microfluidic co-flow of Newtonian (water or PBS) and viscoelastic fluids (PEO) for the size-dependent separation of microparticles. The co-flow condition generates a stable viscoelastic/Newtonian interface, giving rise to the wall-directed elastic lift forces that compete with the center-directed lift forces, and efficiently hinders the migration of microparticles from the Newtonian to the viscoelastic fluid in a size-dependent manner. An almost complete separation of a binary mixture of 1 μm and 2 μm polystyrene particles is achieved by the co-flow of water and a very dilute PEO solution (100 ppm), whereas the sole use of water or PEO could not lead to an efficient separation. This co-flow microfluidic system is also applied for the separation of Staphylococcus aureus (1 μm) from platelets (2–3 μm) with >90% efficiencies and purities.

Graphical abstract: Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles

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Publication details

The article was received on 27 Jun 2017, accepted on 07 Aug 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7LC00671C
Citation: Lab Chip, 2017, Advance Article
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    Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles

    F. Tian, W. Zhang, L. Cai, S. Li, G. Hu, Y. Cong, C. Liu, T. Li and J. Sun, Lab Chip, 2017, Advance Article , DOI: 10.1039/C7LC00671C

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