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A switchable 3D liquid-liquid biconvex lens with enhanced resolution by Dean flows

Abstract

Liquid- liquid (L2) microlenses have great potential in various applications of imaging and detection systems. Traditional ones are almost two dimensions (2D) in shape as the modulation of flow rates in planer chip. There are fundamental difficulties to be applied effectively for cell imaging and analysis due to the limitation of 2D profiles. Here, we demonstrate a feasible design to achieve three-dimensional (3D) L2 biconvex lens to detect flowing cells. Using the auxiliary curved microchannels, a 3D L2 lens is formed by the Dean flows. The shape of the 3D biconvex lens and its focal length can be modulated by tuning the flow rates of the liquids. The 3D light focusing is successfully achieved and the focus length can be modulated in a range of 435 μm, from 3554 μm to 3989 μm in the experiment. The numerical aperture of 3D L2 lens is also measured and its range is 0.175-0.198. Compared to traditional objective lens with same magnification (4× /0.1), the resolution of the 3D L2 biconvex lenses is improved by 1.79 times as it is completely immersed in liquids. Two kinds of cells, mouse myeloma cells sp2/0 and acute promyelocytic leukemia cell NB4, are imaged in the contrast experiments. The time response of experimental manipulation is about 2.7 ms. This 3D biconvex lens shows great application prospect for cells imaging and analysis systems in lab-on-a-chip environment.

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Publication details

The article was received on 06 Jun 2017, accepted on 09 Aug 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7LC00598A
Citation: Lab Chip, 2017, Accepted Manuscript
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    A switchable 3D liquid-liquid biconvex lens with enhanced resolution by Dean flows

    L. Liang, X. Zhu, H. Liu, Y. Shi and Y. Yang, Lab Chip, 2017, Accepted Manuscript , DOI: 10.1039/C7LC00598A

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